Can Organisms be Genetically Engineered to Not Build Drug Tolerance?

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The discussion centers on the concept of drug tolerance, questioning whether it is an evolutionary adaptation to prevent complacency or a chemical necessity. It explores the possibility of genetically engineering organisms that do not develop tolerance to drugs. References to Paracelsus highlight the idea that dosage determines toxicity, linking to broader themes in holistic medicine and cumulative effects. However, the conversation is curtailed by a moderator's insistence on adhering to established scientific principles, stating that speculative thought experiments are not permitted and that only specific inquiries about the mechanisms of tolerance are acceptable.
GladScientist
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Hi everyone. In a thought experiment that I like to frequent, an important question arises. Is tolerance (the body's natural resistance to the effects of drugs) a technique that we've evolved to not grow too content with our current situation? Or, do the laws of chemistry determine that tolerance must exist?

Is it or is it not possible to potentially genetically engineer an organism that does not build tolerance to drugs?
 
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You might want to look up Paracelsus, "The dose is the poison," or words to that effect. Holistic medicine. Cumulative poisons/effects.
 
GladScientist said:
Is it or is it not possible to potentially genetically engineer an organism that does not build tolerance to drugs?
Your questions cannot be answered. We don't allow "thought experiments" here, we stick to mainstream known science. If you have a specific question about how the body builds up tolerance, that would be allowable. This thread is closed.
 

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