Driving for higher fuel efficiency involves maintaining a balance between throttle position and engine RPM. The optimal method is to accelerate with the throttle slightly open while delaying upshifting until reaching higher RPMs, ideally around 35% of redline and 80% of maximum torque. Manual transmissions are generally more efficient than automatics, with shifting at 2000 to 2200 RPM being recommended for better fuel economy. Additionally, keeping tires inflated, using synthetic oil, and maintaining a clean air filter can further enhance fuel efficiency. Overall, driving smoothly and in the appropriate gear is crucial for maximizing miles per gallon.