Changing the origin in a physical context involves adjusting position vectors by adding or subtracting the displacement from the original coordinates. For example, when moving from an origin at (0,0) to a new point (x4,y3), the function must be recalibrated accordingly, resulting in a new equation. The discussion highlights the mathematical representation of this shift using vector notation, specifically with position vectors and constants. The transformation is illustrated through the equation x'=(x(cross)n)+a, showing how to incorporate the new origin into the function. Understanding these adjustments is crucial for accurately modeling physical systems in different coordinate frames.