Does Decarboxylation Occur in Gamma-Keto Acids Under Heat?

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In summary, decarboxylation with heat is a chemical reaction that involves removing a carboxyl group from a molecule through the application of heat. This process is important because it can make molecules more reactive and convert inactive forms into active forms. Many different types of molecules can undergo decarboxylation with heat, and the temperature plays a crucial role in the process. Some applications of decarboxylation with heat include synthesizing new compounds, activating molecules for reactions, producing active forms of vitamins and enzymes, and food production.
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HighFive5
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Homework Statement
Choose the carboxylic acid that would not would not undergo decarboxylation when subject to heat.
Relevant Equations
None needed.
Hello all!

I have learned beta-keto acids are able to undergo carboxylation when subjected to heat. Do gamma-keto acids undergo decarboxylation when subjected to heat as well? If not, why?

I identified C as a gamma-keto acid. Do you agree?

Thank you for your help.
 

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  • #2
Think about the intermediate present in beta keto carboxylates which assists the removal of CO2. Is that possible for your gamma keto compound?
 

What is decarboxylation with heat?

Decarboxylation with heat is a chemical process in which carboxylic acids, such as THC and CBD, are converted into their active forms through the application of heat. This process is commonly used in the production of cannabis edibles and concentrates.

Why is decarboxylation with heat necessary?

Decarboxylation with heat is necessary because the active forms of carboxylic acids, such as THC and CBD, have different effects on the body compared to their inactive forms. Without decarboxylation, ingesting cannabis would not produce the desired psychoactive or medicinal effects.

What temperature is ideal for decarboxylation with heat?

The ideal temperature for decarboxylation with heat is between 220-240 degrees Fahrenheit (104-115 degrees Celsius). This temperature range ensures that the carboxylic acids are converted into their active forms without damaging them.

How long does decarboxylation with heat take?

The time it takes for decarboxylation with heat to occur depends on the temperature and the amount of material being decarboxylated. Generally, it takes 30-45 minutes for decarboxylation to occur at 220-240 degrees Fahrenheit.

Can decarboxylation with heat be done at home?

Yes, decarboxylation with heat can be done at home using an oven, a slow cooker, or a sous vide machine. It is important to carefully monitor the temperature and time to ensure the best results.

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