To design a buck converter with low power losses, consider using a MOSFET instead of a diode for improved efficiency. Employing synchronous rectification is beneficial, especially for lower output voltages like 3.3V or 5V, while a low-drop Schottky diode can suffice for higher voltages. Reducing switching frequency can also enhance efficiency, but requires larger inductors and capacitors to manage output ripple. Careful PCB layout is crucial to minimize resistive losses, and selecting low ESR capacitors and optimal transformer core materials can further improve performance. Overall, balancing frequency, component selection, and layout is key to achieving low power losses in buck converters.