Practical methods for detecting very small currents in nano or pico amperes include using picoammeters, with recommendations for devices from manufacturers like Keithley. Users are also interested in measuring small magnetic flux variations without relying on induced AC current, as picoammeters primarily measure DC current. Concerns were raised about the limitations of commercial picoammeters, particularly their voltage range, which typically caps at around 500 to 700 volts. The discussion emphasizes the need for specialized equipment to handle floating measurements of such low currents. Overall, the thread highlights the challenges and solutions in measuring extremely low electrical currents and magnetic flux changes.