To find the polynomial equation with three zeros, including -5 and the complex pair 4+3i and 4-3i, the polynomial can be expressed as c*(x+5)(x-4-3i)(x-4+3i), where c is a constant. The requirement that all coefficients are real numbers implies that the polynomial must include both complex conjugate zeros. To determine the constant c, the polynomial must satisfy the condition f(2)=91. The discussion highlights the importance of correctly applying the initial condition to find the leading coefficient and ensure the polynomial meets the specified criteria. Understanding these relationships is crucial for accurately constructing the polynomial equation.