Gas Chromatography: Polar Compounds & Retention Time

AI Thread Summary
When selecting a liquid stationary phase for chromatography, the principle of "like dissolves like" is crucial. If the compound of interest is polar, a polar stationary phase should be chosen to enhance interactions and improve retention time. Polar compounds tend to elute faster when paired with a polar stationary phase due to stronger interactions, while nonpolar compounds would generally elute slower under the same conditions. The retention time is influenced by the degree of interaction between the solute and the stationary phase, with polar solvents facilitating quicker movement of polar compounds. Additionally, polar compounds can interact through various intermolecular forces such as hydrogen bonding and dipole-dipole interactions.
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it says when i choose the liquid stationary phase, then i have to use the rule; "like dissolves like". i wonder if the compound i am interested in is polar, this means that the stationary phase i choose must also be polar, right? how would you predict the retention time of my compound? would it be eluted faster or slower than other nonpolar compounds?


BTW how can polar compounds be interacted with each other?

thanks again! :smile:
 
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Retention time involves some interactions between solute (your compound dissolved in a solvent) and the stationary phase. The high polarity of solvent drives your spot faster if your compound is also polar; and vice versa (like dissolves like principle).
 
thanks alot!
 

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