Genetic Structure: Does Age Affect It?

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Genetic structure remains largely stable throughout a person's life, with the genome remaining unchanged from fertilization to death. However, the epigenome, which consists of chemical modifications like methyl groups that regulate gene expression, does undergo changes over time. These alterations can influence how genes are activated or silenced. Additionally, cells can experience genetic changes due to epigenetic programming or damage, which can lead to serious conditions such as cancer. The discussion emphasizes the distinction between stable genetic material and the dynamic nature of the epigenome.
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Does your genetic structure change as you get older? I guess it's just the levels of NFKappa and things iike that that change?
 
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Please elaborate on genetic structure, are you talking about karyotypes, DNA structures, etc?
 
Ideally, your genome does not change at all, from the fertilization of an egg until the day you die. Your epigenome, however -- the collection of methyl groups and so on strapped onto your DNA that promote or inhibit certain genes -- can and does change throughout life.

- Warren
 
Cells can acquire changes in their genetic structure, either through epigenetic programming (what Chroot mentioned) or through damage/errors. Processes like these can lead to cancer.
 
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