To run a Perl program on a Windows platform, the user must ensure that ActivePerl is correctly installed and that the PATH environment variable includes the directory where Perl is installed, typically C:\Perl\bin. To execute a Perl script, open a command prompt (cmd), navigate to the script's directory using the "cd" command, and run the script with "perl scriptname". If issues arise, checking the installation and PATH settings is crucial. In the discussion, users also shared experiences with handling large text files in Perl, noting that while Perl excels in string manipulation, it struggles with large datasets. Suggestions included optimizing the script for efficiency and exploring alternative programming languages like Python for better readability and performance. Users discussed specific coding challenges, such as capturing data from formatted text files and leveraging regular expressions for pattern matching. The conversation highlighted the importance of understanding basic command-line operations and the potential need for more comprehensive documentation from Perl resources.