Ointments for treating skin burns offer several advantages, including the delivery of antibiotics, limited barrier protection against pathogens, and physical relief through numbing agents or lubrication of scabs. However, there are notable drawbacks. Ointments can restrict oxygen access, potentially promoting harmful bacteria in severe burns. The natural scaling of the skin often serves as a better barrier against pathogens. Additionally, improper application, such as using ointments without washing hands, can introduce bacteria into the wound, particularly with products like aloe vera that lack broad germicidal properties. Maintaining sterility during application is crucial to prevent cross-contamination. There is also a suggestion that ointments could be developed to enhance p53 upregulation for better healing outcomes.