To solve for V₀ in the equation x = x₀ + V₀t + ½at², one can rearrange it to V₀ = (x(t) - x₀ - ½at²)/t or V₀ = (x(t) - x₀)/t - ½at. The discussion highlights the need for known variables, specifically time and acceleration, to accurately determine V₀. In the context of a ball thrown from a 95-meter cliff that strikes the ground in 5 seconds, it’s essential to consider the effects of free fall and the possibility of the ball being thrown upwards before descending. Understanding the motion involves calculating the distance fallen and the initial velocity required to achieve the given conditions.