Converting a cylinder made of semipermeable material to a sphere affects the pressure gradient due to the differing geometries. In a cylinder, the pressure profile decreases in proportion to the radius, while in a sphere, it decreases in proportion to the square of the radius. The discussion emphasizes the importance of understanding fluid flow dynamics and the pressure difference across the shell in both cases. Participants suggest conducting preliminary research on osmotic pressure and fluid dynamics to better grasp the underlying principles. Overall, the conversation highlights the need for foundational knowledge before delving into specific calculations regarding pressure gradients.