To calculate the heat of reaction (ΔHrxn) for single replacement reactions, it's essential to gather specific details about the reaction, including the reagents, their phases, and any catalysts involved. The common equations for determining ΔHrxn include ΔH°=∑ΔvpΔH°f(products)−∑ΔvrΔH°f(reactants) and ΔH=q=mcΔT. In the context of mixing CuSO4 and iron in water, the calorimetry equation ΔE=mCΔT can be applied to measure the temperature change. To find the overall heat of the reaction experimentally, one must record the temperature change and then calculate ΔE. To convert ΔE to ΔH, it is necessary to divide by the number of moles of the limiting reactant, which provides the molar heat of the reaction. This approach ensures accurate results for the heat of reaction in a lab setting.