To calculate total resistance in circuits, identify resistors in series and parallel, simplifying them step by step. The formula for resistors in series is R = R1 + R2 + R3, while for parallel resistors, it is (1/R) = (1/R1) + (1/R2) + (1/R3). One participant calculated the total resistance for the second circuit as 25/84 Ohms but later corrected it to 84/25 Ohms after realizing a simplification error. Another user confirmed the methodology of treating pairs of resistors in parallel and then adding them in series is valid. Overall, the discussion emphasizes careful step-by-step simplification to arrive at the correct resistance values.