Kinetic energy equations such as KE = ½ m ⋅ v² are only valid at speeds much less than the speed of light (c) due to the effects of relativity. As objects approach light speed, their mass effectively increases, necessitating the use of the Lorentz factor in calculations. The relativistic kinetic energy equation is expressed as KE = (γ - 1)mc², where γ represents the Lorentz factor and m is the rest mass. This reflects the dependence of kinetic energy on the reference frame in both Newtonian and relativistic mechanics. Understanding these changes is essential for accurate calculations in high-speed physics scenarios.