Manganese Toxicity: Investigating Molecular & Systems Level Changes

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Manganese toxicity is associated with neurological issues resembling Parkinson's disease, including cognitive dysfunction and symptoms similar to ADD. The discussion highlights a need for clarity on the molecular and systemic changes that occur due to manganese exposure, as the connection between toxicity and symptoms is recognized but not fully understood. Additionally, there is interest in exploring how toxic levels of other transition metals, such as iron and calcium, may impact health. The conversation emphasizes the complexity of these relationships and the gaps in current research regarding the mechanisms of toxicity.
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I've done a bit of reading about manganese toxicity recently, and I was just wondering if anyone had anything to contribute about this topic. It seems evident from the research I've read that excess manganese (ingested or inhaled) is linked to problems in the nervous system similar to Parkinsons, as well as mild ADD like symptoms, and general cognitive dysfunction.
How do you go from manganese toxicity to changes at the molecular/systems levels? The association is evident, but there's still some "magical hand waving" going on between exposure and symptoms I would like to understand. I'd also be interested in how toxic levels of iron, calcium or any other transition metals could affect an organism.
 
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