To find the minimum values of t_1 and t_2 given t_0=0 and t_3=5, the use of Mathematica's NMinimize function is recommended. The provided code integrates a specific function across defined intervals and applies constraints to ensure t_0 <= t_1 <= t_2 <= t_3. The integration involves exponential decay and a quadratic term, which is computed efficiently in a matter of seconds. For larger numbers of intervals, such as extending from t_0 to t_9, the same approach can be adapted by modifying the integration and constraints accordingly, although the complexity may increase with more variables. The discussion emphasizes the effectiveness of Mathematica for this type of optimization problem, especially compared to using Excel Solver.