Norganic cofactors such as metal ions permanently bound

[lha08]

Homework Statement

I have a small question, are inorganic cofactors such as metal ions permanently bound or temporarily bound to enzymes...? i can't find any info concerning this..and if anyone could tell me if i understand this concept properly:
Cofactors are separated into either organic or inorganic categories. In this case, inorganic are metal ions such as Zn+2, Mg+2, etc (permanently bound?), while organic cofactors are further separated into coenzymes (temporarily binds to enzyme and then released to react with other enzymes--formed by weak noncovalent bonds (?)) and prosthetic groups (permanently binds to enzyme--formed by covalent bonds (?)). Organic cofactors are usually made from vitamins.

Homework Equations

The Attempt at a Solution

 

[Nino MMP]

In general, inorganic cofactors are permanently bound to the enzyme. This is because they are usually bound to the enzyme by strong covalent bonds. Organic coenzymes are usually temporarily bound to enzymes through weak noncovalent interactions. Prosthetic groups, on the other hand, are permanently bound to enzymes and are typically formed by strong covalent bonds. Prosthetic groups are usually derived from vitamins.