To produce 2,000 volts at low amperage from a 12V power source, options include using a Van der Graaf generator or a Tesla coil. A voltage multiplier circuit utilizing cascading diodes and capacitors can also be effective, especially if 12V AC is available. Safety is paramount when working with high voltages, and proper precautions must be taken to avoid fatal accidents. It is crucial to have a solid understanding of high voltage systems before attempting any experiments. Consulting with a qualified engineer or teacher is highly recommended for those inexperienced in high voltage work.