You don't know what's happened until you see it, no. And my understanding is that there are parts of the universe you'll never see. But you can talk hypothetically about what's happening now somewhere you can't see (or won't see until later). The only extra wrinkle relativity introduces is a requirement to define what you mean by "now" before you do.
Saying simultaneity is undefined where you can't see is a bit like saying the back of your head is undefined because you aren't sitting between a pair of mirrors. I suppose it's possible that the back of my head doesn't exist at the moment, but if so it's strange how it comes into existence the instant someone comes into the room behind me.