i'm not certain I'm interpreting the question correctly, but if so, I've had a similar question for a while now. now, where this comes from is that some people, under influence of certain hallucinogenic drugs (lets say from mushrooms), claim some sort of ability to suddenly "get it" and understand grand concepts about the true nature of the universe. there is even an (untrue) urban legend about the structure of DNA being discovered under influence of LSD.
now, the curious thing to me is that i see this even from people i know to be reasonably intelligent when sober. yet, i still think it is all hooey. reason being, i think judgement is obviously being impaired. what i don't understand is what the mechanism is. I'm guessing that somewhere in the brain, there is a mechanism or three that make comparisons and determine whether an experience agrees with the known facts. but that's really vague and unsatisfying.
however, there is a process we all experience that may lead to a conclusion, and that is dreaming. dreams are often quite bizarre, and yet we seem to have the ability to suspend rationality during dreaming and accept our alternate reality as reasonable. and there is another hallucinogenic drug that gets released when we sleep: http://en.wikipedia.org/wiki/Dimethyltryptamine" . OK, apparently even this is still hypothetical. but here in my wake state, it at least seems a rational way of explaining some of the weirdness of dreaming, even if the mechanism is maybe nowhere nearer.
so what else is there to go on? anyone? Beuller?