Key software options for pipe work design include Intergraph's CADWorx and CAESAR II for AutoCAD/BIM users, as well as Bentley's AutoPLANT and AutoPIPE. Google Sketchup offers a pipe design app, though its capabilities may be limited. For compact and custom routings, SolidWorks, Inventor, SolidEdge, and ProE are recommended. AFT Fathom is highlighted for analyzing fluid flow in piping systems. The discussion emphasizes the importance of selecting software that meets specific material and design standards.