DC offset in an amplifier refers to a deviation from 0V, resulting in a shift of the waveform's mean voltage, which can be visually represented on an oscilloscope. This offset can manifest as a voltage level above or below zero, affecting signal integrity. To eliminate DC offset, capacitors are commonly used as filters since they block DC while allowing AC signals to pass, effectively removing the offset voltage. This method results in a cleaner waveform, essential for accurate signal processing. Understanding and addressing DC offset is crucial for optimal amplifier performance.