What is the Most Dangerous Chemical?

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SUMMARY

The forum discussion centers on identifying the most dangerous chemical, with participants highlighting various substances based on toxicity and hazard. Sodium Cyanide (NaCN) is mentioned as highly poisonous, while Botulinum toxin is noted for its extreme lethality at minuscule doses, with an LD-50 of 1.3–2.1 ng/kg. Other contenders include Polonium, which is lethal in very small quantities, and Dihydrogen oxide, which poses risks through both consumption and inhalation. The conversation emphasizes the complexity of defining "dangerous" in terms of both toxicity and exposure routes.

PREREQUISITES
  • Understanding of chemical toxicity and hazard classification
  • Familiarity with terms like LD-50 and exposure routes
  • Knowledge of specific chemicals such as Botulinum toxin and Sodium Cyanide
  • Basic principles of biochemistry related to cellular respiration and chemical interactions
NEXT STEPS
  • Research the properties and effects of Botulinum toxin and its applications in medicine
  • Study the mechanisms of action and risks associated with Sodium Cyanide
  • Explore the safety protocols for handling highly toxic substances like Fluoroantimonic acid
  • Investigate the environmental and health impacts of Dihydrogen oxide (water) in various contexts
USEFUL FOR

Chemists, toxicologists, environmental scientists, and safety professionals interested in chemical hazards and their implications for health and safety.

  • #31
iScience said:
i'm told hydrazine (C2H4) is quite up there

DNA based viruses.
you are right.DNA based viruses
 
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  • #32
trichloroanisole ... I suspect it was first developped by algerian extremists to drive out the French colonists. Alone the thought of the desaster a muslim extremist might cause in a region like Bordeaux with only a few drops makes me shudder.
 
  • #33
DrDu said:
trichloroanisole ... I suspect it was first developped by algerian extremists to drive out the French colonists. Alone the thought of the desaster a muslim extremist might cause in a region like Bordeaux with only a few drops makes me shudder.

Is it a poison or an explosive?
 
  • #34
Technically neither.
 
  • #35
Along the direction of the silent but deadly, consider plain old phosgene.
Borek said:
Technically neither.

Ahhh Wikipedia enlightens. Yes, in the hands of a terrorist, it could bring Western Civilization crashing down on our jazzed and inebriated heads?
 
  • #36
Mark Harder said:
Ahhh Wikipedia enlightens. The dastardly effects include making coffee and wine taste like treated fiberboard?
:-) and that at concentrations in the ng/l range.
 
  • #37
I agree with DNA. Without DNA there is no danger and no death.
 
  • #38
Hydrogen cyanide is the most dangerous chemical.Cyanide kills by binding to the iron in our blood cells and choking them off, removing their ability to transfer oxygen throughout the body.
 
  • #39
msarts said:
Hydrogen cyanide is the most dangerous chemical.Cyanide kills by binding to the iron in our blood cells and choking them off, removing their ability to transfer oxygen throughout the body.
You're describing carbon monoxide, which binds to iron found in the heme groups in hemoglobin, shutting down oxygen transport. Cyanide binds to iron in the heme groups in cytochrome c oxidase, which is found in mitochondria and is responsible for cellular respiration. In fact, cyanide is really useful in certain biochemistry experiments where you need to shut down cellular respiration to examine an oxygen-sensitive process.
 
  • #40
DMT. Trust me on this one.
 
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  • #41
I really hope terrorists do not come across this forum.
 
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  • #42
You mean 'politicians'?
 
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  • #43
I do agree that the parameters of the question are poorly defined, but I'll still throw out a few of the most dangerous things that I've had to work with.

Trifluoromethanesulfonic acid (Triflic Acid): pKa around the -13 range, nasty stuff.
Fluoroantimonic acid: The most potent superacid known, pKa around the -25 range. This stuff is ridiculously dangerous.
Dimethylsulfoxide (DMSO): Anything that penetrates the skin so easily deserves a mention.

...and pyridine! Well, pyridine is mostly dangerous to your nose. But, like others have said, the question is too vague.
 
  • #44
Kekule said:
Fluoroantimonic acid: The most potent superacid known, pKa around the -25 range. This stuff is ridiculously dangerous.
It burns through just about everything, except teflon, right? Can you describe the extra laboratory precautions that you had to take when handling that stuff ? And (if you are at liberty to) what you used it for ?
 
  • #45
certainly said:
It burns through just about everything, except teflon, right? Can you describe the extra laboratory precautions that you had to take when handling that stuff ? And (if you are at liberty to) what you used it for ?

Yes, it is contained in Teflon. You make it fresh if you're planning on using it, because good luck storing it with any success. And of course, it instantly reacts with even the slightest amount of moisture in the air. So you have to use a glove box, but you also grab some extended tongs so that you don't have to come into contact with it at all. Here is some discussion about it you might find interesting:

http://en.wikipedia.org/wiki/Talk:Fluoroantimonic_acid#1016_or_1019.3F

It is very, very nasty stuff. When I used it, it was for reactions related to alkane metathesis (yes, alkane and not alkene). I'd prefer to never come near the stuff again.
 
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  • #46
nightingale said:
I would say Sodium Cyanide (NaCN).
Sodium cyanide is actually quite safe to use as long as it is used properly with the proper PPE.
 
  • #47
Botulinum toxin, one of only two substances (the other being the narcotic angel dust) that is lethal in nanogram levels.About 80kg is enough to kill about 8 billion people.Of course the most dangerous substance you are likely to encounter in the workplace is hydrofluoric acid. It is highly corrosive, will dissolve glass, seep into your skin, burn through to the flesh below before you would even feel it and dissolve your bones. It is also acutely toxic and will damage your internal organs and it only takes a fist sized spill on your skin at 10% concentration to be deadly.
 
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  • #48
Mad scientist said:
Sodium cyanide is actually quite safe to use as long as it is used properly with the proper PPE.

Very true. I used to handle sodium cyanide fairly often. Gloves(long ones), lab coat, respirator, and a steady hand. And best not to drop it in acid outside a glove box.That's how California used to execute human beings. For that matter, don't mix vinegar, often used to clean windows, and "clorox".

Botulinum toxin is a good candidate as per Mad scientist. But as someone mentioned, the parameters matter. I had injections of the stuff to mitigate some inherited wrinkles.
Other than a tendency to go into convulsions there were no side effects. :wink:
 
  • #49
Greg Bernhardt said:
A lot of people die from H2O :smile:
That was what SteamKing said in post number 5.
 
  • #50
Carbon dioxide kills a lot of people too.
 
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  • #51
Thank you all for help .i have a question about this=
http://beforeitsnews.com/alternative/2013/01/top-10-most-deadly-poisons-known-to-mankind-2526172.html
i will ask it later...
 
  • #53
Dimethylcadmium
 
  • #54
Emmanuel_Euler said:
what is the Most Dangerous Chemical or poison in the world?

Why not now consult the Merk Index for all the chemicals suggested and find the one with the most lethal dose. I think it's called LD50 or something like that. Tally the results and then write a nice summary quantifying (like Chemists do) the results from least to most. I suggest finding the top 10 quantifiable most toxic man-made compounds (or 10 of the most . . .) to get practice doing real chemistry. Also if you don't mind, kindly explain why chemically, what chemically, causes these substances to be so toxic.

For example, purines and pyrimidines are extremely toxic because they have similar structures to DNA and thus have the capability of interfering with DNA replication. Is this group of compounds in a list of "most toxic"?
 
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