Which factors are important for plutonium production?

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Plutonium production is significantly influenced by specific burn-up rates, with lower burn-ups under 1000 MWd/tU being optimal for generating weapons-grade plutonium. Higher burn-up levels lead to increased amounts of plutonium-240 and other isotopes, complicating weaponization and raising the risk of a fizzle. The choice of fuel also affects isotopic composition; natural uranium reactors provide more U-238 for neutron capture, which is favorable for producing weapons-grade plutonium. In contrast, low-enriched uranium (LEU) reactors may yield a less desirable isotopic mix, even if burn-up levels are equivalent. Overall, reactor design and fuel type are crucial for maximizing plutonium production efficiency.
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As far as I understand plutonium production is mainly a function of the spesific burn-up. A low burn-up of under 1000 MWd/tU is preferred to produce weapongs-grade plutonium. The higher the burn-up the more pu-240 and other plutonium isotopes that makes production of weapons a bit more difficult and increases the risk of a fizzle.

How does the enrichment level play into this? A reactor fueled with natural uranium will have more u-238 available for neutron capture than a reactor fueled with LEU. Will a LEU reactor produce a better/worse composition of plutonium isotopes compared to a NU reactor if their burn-up levels were equal?
 
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A reactor fuelled with natural uranium would be your choice to make weapons grade plutonium. The design of fuel and moderator (which needs to be heavy water or graphite) is such that it maximises the production of plutonium, the irradiation time will determine the isotopic composition of your plutonium.
 
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