The discussion centers on the comparison of steric hindrance between an amino group (NH2) and an ethyl group (CH2CH3). The primary point of analysis is based on molecular size, with the ethyl group having a molecular weight of 29 g/mol compared to the amino group's 16 g/mol. This size difference indicates that the ethyl group exhibits greater steric hindrance than the amino group. The conclusion drawn is that when assessing steric hindrance, size is a key factor, and in this case, the ethyl group is larger and thus more hindering.