Microcontrollers like Arduino and Raspberry Pi can fail in a vacuum due to overheating, as there is no air to dissipate heat, leading to component failure. At -30inHg, the devices powered off and did not reboot, indicating a potential thermal issue rather than a power supply failure. Even if electrolytic capacitors appear intact, they may still be susceptible to failure under extreme conditions. The discussion highlights the importance of considering thermal management in vacuum environments, as traditional cooling methods are ineffective. Modifying software to power down the devices between data samples could mitigate overheating risks.