Microwaves primarily heat water due to its molecular dipole moment, which allows it to respond effectively to the oscillating electric field generated by microwave radiation. This interaction causes water molecules to vibrate, breaking and reforming hydrogen bonds, which generates heat. While it's a common belief that microwaves only heat water, they can also heat other polar substances like sugars and certain fats, though lipids generally heat poorly due to their low dielectric loss factor and non-polar nature. The heating process is based on dielectric heating rather than resonance, meaning that any molecule with a dipole moment can be heated in a microwave. Non-polar molecules, such as benzene, do not heat effectively in microwaves. The discussion also touches on the potential for using frequency to alter water's molecular bonds without heating, but this concept remains speculative.