Transcription factors - how does it unbind

  • Thread starter Thread starter jsmith613
  • Start date Start date
  • Tags Tags
    Factors
AI Thread Summary
Transcription factors unbind from DNA to halt transcription primarily through reversible non-covalent interactions. These interactions, which include hydrogen bonds, ion pairs, van der Waals forces, and the hydrophobic effect, are relatively weak and comparable to the thermal energy present in the system. As a result, thermal fluctuations can provide sufficient energy to disrupt these bonds, allowing transcription factors to detach from the DNA. This mechanism is crucial for regulating gene expression and ensuring that transcription occurs only when necessary.
jsmith613
Messages
609
Reaction score
0
how do transcription factors UNBIND from the DNA to prevent further transcription??
 
Biology news on Phys.org
Transcription factors interact with DNA non-covalently and all non-covalent binding reactions are reversible. Typically, binding occurs through a variety of weak intermolecular forces (e.g hydrogen bonds, ion pairs, van der Waals interactions, hydrophobic effect) whose strength is on the order of the thermal energy of the system. Therefore, thermal fluctuations can supply enough energy to break the bonds between transcription factor and DNA, releasing the transcription factor from the DNA.
 

Thread 'Australian Funnel-web spiders and delta-hexatoxin (aka Versutoxin)'

https://www.discovermagazine.com/the-deadliest-spider-in-the-world-ends-lives-in-hours-but-its-venom-may-inspire-medical-miracles-48107 https://en.wikipedia.org/wiki/Versutoxin#Mechanism_behind_Neurotoxic_Properties https://www.sciencedirect.com/science/article/abs/pii/S0028390817301557 (subscription or purchase requred) he structure of versutoxin (δ-atracotoxin-Hv1) provides insights into the binding of site 3 neurotoxins to the voltage-gated sodium channel...
View full post »

Thread 'Here comes COVID-19 version BA.2, BA.4, BA.5,...'

Popular article referring to the BA.2 variant: Popular article: (many words, little data) https://www.cnn.com/2022/02/17/health/ba-2-covid-severity/index.html Preprint article referring to the BA.2 variant: Preprint article: (At 52 pages, too many words!) https://www.biorxiv.org/content/10.1101/2022.02.14.480335v1.full.pdf [edited 1hr. after posting: Added preprint Abstract] Cheers, Tom
View full post »

Similar threads

Transcription Factor Inhibition vs. Gene Methylation?
Replies
3
Views
2K
Are There Exceptions to Transcription Factors Binding to Specific DNA Sequences?
Replies
1
Views
1K
Why does the DNA codon ACG code for threonine in the RNA codon table?
Replies
12
Views
3K
Common name translation and transcription molecules?
Replies
3
Views
2K
Medical Progress for Gene Therapy and CRISPR against Blood Diseases
Replies
2
Views
2K
Mathematical process for protein folding
Replies
5
Views
3K
LINE1 Transcripts Needed to Get Past 2 Cell Stage in Mammals
Replies
1
Views
2K
How does academic transcripts translation work?
Replies
4
Views
2K
What are Immediate Early response Genes?
Replies
6
Views
2K
COVID Remdesivir - a possible treatment for COVID-19?
2
Replies
74
Views
11K

Hot Threads

Recent Insights

Back
Top