Rare Phenomenon: What Happens When 2 Sperm Fertilize the Same Egg?

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When two sperm fertilize the same egg, a rare occurrence known as polyspermy can lead to significant chromosomal abnormalities. Typically, the egg's membrane quickly changes its electric potential to prevent this, but if it were to happen, the resulting zygote would likely be triploid instead of the normal diploid. This condition often results in immediate cell death or the development of a partial hydatidiform mole, which is a tumor-like growth. Such moles can be concerning due to their association with uterine cancer and the emotional distress of a false pregnancy. In plants, similar triploid conditions can occur, where offspring may survive but cannot reproduce sexually due to disrupted meiosis.
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Hello,

Quick Q. What happens when 2 sperm fertilize the same egg? Obviously it's extremely rare due the sodium ion channel's ability to quickly change the electric potential across the egg's membrane, preventing polyspermy.

But what would happen if two sperm nailed the egg at EXACTLY the same time?

Thanks.
 
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this interests me. Though i honestly don't know much about it. well anything beyond meiosis and the chromosome diseases.

But your question seems a lot like klinefelter/jacobs where u have a double male Y chromosome.

and well you can study up on those syndromes.

but don't take my word for this. i have no idea if this is how they get it or not.
 
Nothing would happen. Due to the chromosome abnormality (triploid instead of diploid), the cell wouldn't survive.
 
You might end up with immediate cell death or if the cell persists, you might get a partial hydatidiform mole arising from diandry (two haploid sperms fertilising a haploid ovum giving a triploid zygote).
 
Curious3141 said:
You might end up with immediate cell death or if the cell persists, you might get a partial hydatidiform mole arising from diandry (two haploid sperms fertilising a haploid ovum giving a triploid zygote).
Oh, I forgot about moles. Scary because of their correlation to uterine cancer, not to mention that you think you're pregnant and find out it's a nasty clump of tumor-like cells, and a year-long wait before you're allowed to try again.
 
In plants, this actually happens sometimes. The offspring ends up triploid, so it sometimes dies, but triploid plants can survive sometimes. They just can't reproduce sexually because everything gets messed up in meiosis.
 
Popular article referring to the BA.2 variant: Popular article: (many words, little data) https://www.cnn.com/2022/02/17/health/ba-2-covid-severity/index.html Preprint article referring to the BA.2 variant: Preprint article: (At 52 pages, too many words!) https://www.biorxiv.org/content/10.1101/2022.02.14.480335v1.full.pdf [edited 1hr. after posting: Added preprint Abstract] Cheers, Tom
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