Vaccine Definition and 67 Threads

Placebo/control group has 800 people. They aren't given the vaccine. 60 of them develop the disease Treatment group has 1000 people. They're given the vaccine. 15 develop the disease It seems there's a formula viz ##\frac{p_1 - p_2}{\sqrt{p (1 - p)}\left(\frac{1}{n_1} + \frac {1}{n_2}\right)}##...

I got my first COVID infection sometime last weekend (best guess). Mild symptoms kicked in Monday evening (in retrospect). Spent most of yesterday in bed with fever chills, a bit worse and longer-lasting than the aftereffects of the earlier COVID vaccinations. Test this morning confirmed COVID...

Precis of a news report from today's Courier Mail. The University of Queensland clamp technology knocked out because it gave false positives to HIV tests is set for human trials early next year. Scientists have re-engineered the clamp, dubbed Clamp2, so there is no diagnostic interference. CEP...

Interesting new development... https://www.newsnationnow.com/health/fentanyl-vaccine-may-have-been-discovered-researchers/?utm_campaign=NewsNation-trending-now&utm_source=kron4.com&utm_medium=newsnation-cross-brand

https://www.theatlantic.com/science/archive/2022/09/mrna-covid-vaccine-booster-lymphoma-cancer/671308/

Source: https://www.ema.europa.eu/en/news/ema-starts-rolling-review-covid-19-vaccine-hipra-phh-1v See also: https://clinicaltrials.gov/ct2/show/NCT05246137 Source: https://pharmaboardroom.com/interviews/carles-fabrega-managing-director-human-health-hipra/

It is well known that RNA viruses mutate very quickly. Hence, it is said that it is very hard to develop an effective vaccine against it. With HIV and influenza RNA viruses the scientific world is still facing difficulty in developing effective long-term vaccines against them. Most influenza...

Like the name, are all 3 shots of Pfizer Covid vaccine identical in composition or they are different formula following the mutation of the virus? I took all 3 shots, just curious whether it's more of the same.

On Feb 28th, the anti-vaccination group "Doctors for Covid Ethics" wrote a first open letter with questions to the European Medicines Agency (EMA) regarding safety concerns of mainly mRNA vaccines. They have the hypothesis, that the LNPs of an mRNA vaccine go partly from the injection site into...

I have been trying to convince someone that it is wrong to compare the death percentages of two different populations (percentage of death of Covid-19 cases per category: vaccinated vs unvaccinated) in an uncontrolled setting (i.e. real-world data), and conclude that the Covid-19 vaccine does...

Hey, I found these interesting articles about a proposed way of vaccinating people while also applying a biomarker on them which would help remember one's vaccination status. https://news.rice.edu/2019/12/18/quantum-dot-tattoos-hold-vaccination-record/...

In my understanding, in the human host, the Oxford–AstraZeneca vaccine delivers the DNA genetic code for the production of spike proteins of the SARS-CoV2 virus, inside a vector virus. DNA vaccines deliver them through plasmids. Apart from this delivery mode, is there any difference between the...

Well, now that the Pfizer vaccine has full FDA approval, they have decided to give it a new name, "Comirnaty". And believe it or not, they actually have reasons for putting that name together... https://www.kron4.com/trending/comirnaty-whats-the-story-behind-the-new-pfizer-vaccine-name/ :-p...

When mRNA/LNP vaccine gets injected into the upper arm (30 µg for BionTech/Pfizer, 100 µg for Moderna), small amounts get distributed to other organs. Source: https://blogs.sciencemag.org/pipeline/archives/2021/01/21/mrna-vaccines-what-happens Source...

Well, if the Delta variant wasn't enough, now this seems to be rearing it's head. Also continued https://news.yahoo.com/delta-infections-among-vaccinated-likely-192553854.html

How can it be that some people develop next to no immunity , cell memory after a Covid infection or vaccination? Immunity develops after the body sees and fights off foreign protein aka virus presenting within the body, so whichever has gotten infected with the virus has to undergo these steps...

Man this is killing me (figuratively I hope). I know I’m whinging, but I rarely get sick, and here I am experiencing full on flu symptoms along with a slightly discomfortable chest after the 2nd Pfizer. In addition to the sore arm. Being sick sucks, especially when it’s fake sickness meant to...

This applies to the Pfizer vaccine. Article dated May 13, 2021. https://www.nature.com/articles/d41586-021-01299-y Older people who waited 11–12 weeks for their second jab had higher peak antibody levels than did those who waited only 3 weeks. ...could boost antibody responses after the second...

Several news sites (such as) have reported a 75% effective vaccine (phase 2 test) against malaria, a big killer of humans (greater than 400,000/year). Could not find original report. This will be important if it holds up.

I am confused about the 'hoopla' around Oxford's vaccines clotting issue. It is an issue with all the vaccines: https://www.prnewswire.com/news-releases/blood-clotting-needs-to-be-watched-with-all-covid-vaccines-states-the-association-of-american-physicians-and-surgeons-aaps-301262360.html Am...

VERY DUMB QUESTION: Could I have "killed" my Moderna vaccine (or its efficacy)? I got a Moderna shot at 9AM today. At 10:45, the band aid "rubbed off" my arm when I was doing some moving around. I looked at the wound site and it was just a tiny pink "bump." No bleeding that I could tell. I...

If anybody is interested in the woes of the vaccine rollout here in Aus see the following: https://www.abc.net.au/news/2021-04-04/australia-covid19-vaccine-supply-gaps-void-to-be-filled/100043348 Personally, I would feel a lot better if a logistics expert was in charge of it. We have at least...

Check out: https://www.pfizer.com/news/press-release/press-release-detail/pfizer-initiates-phase-1-study-novel-oral-antiviral If it works out may change the vaccine landscape entirely. Thanks Bill

Are cancer vaccines a super new thing? I have not heard of a vaccine for cancer before. https://www.nature.com/articles/s41586-021-03363-z

Here is my understanding of how an mRNA vaccine works and some questions where I am not clear: I understand that an mRNA vaccine is delivered via lipid spheres containing the mRNA,. The cell brings it inside the cell thinking it's fat? Then the mRNA is read by the cell machinery to produce the...

(This added about a month after this thread opened: It turns out I'm a real outlier for side effects to the vaccine, so don't let this post scare you off. My wife says every time I catch a cold or something that it hits me hard. Of course to me that is 'normal.' :doh:) A few days ago a...

https://berthub.eu/articles/posts/reverse-engineering-source-code-of-the-biontech-pfizer-vaccine/ Would be interested to hear some expert comment on the above. I could not understand much of it but perhaps someone could summarise ? Is the comparison/analogy with computer programming valid?

The Oxford vaccine was approved here in Aus - finally: https://www.tga.gov.au/media-release/tga-provisionally-approves-astrazenecas-covid-19-vaccine It recommends a second dosing 12 weeks apart. The article in the local paper announcing this said with a 12 week second dose it had 82% efficacy...

Hi All Here is how the Aussies are making the Oxford Vaccine: https://www.abc.net.au/news/science/2021-02-12/covid-19-vaccine-oxford-astrazeneca-adenovirus-csl-manufacturing/13140104 Thanks Bill

Paul Biensiasz is a virologist at Rockefeller Medical, he authored this on twitter, titled "musings of a pissed virologist"

(Sorry if this has already been addressed in one of the other COVID-19 threads. If it has, I can delete my question or merge it into the other thread. Thanks.) I work part-time in EMS, so I was in tier 1A for public vaccinations for COVID-19 here in Northern California. I got my first...

There is a controversy world over, over the vaccine related (or so assumed) deaths and injuries. Suppose a person dies within a few days after vaccination, a doubt may arise in everyone, if the vaccine had induced the death or not. To prove or disprove the complication of vaccine as the real...

I hope this helps some of you.

Here is the official peer reviewed Pfizer vaccine study published in the New England Journal of Medicine: https://www.nejm.org/doi/full/10.1056/NEJMoa2034577 This is a follow-up piece that describes what an emergency use authorization means and gives a perspective about follow-up...

A paper in Nature Medicine reports data from a phase I clinical trial of a new flu vaccine strategy that targets the stalk of the influenza virus's HA protein, a region that has much less variation between different flu strains...

Good morning everyone. I woke up today and opened up Facebook only to see someone posting a meme about how in 70 years we've only developed a flu vaccine that's 40% effective, yet in 10 months we've developed a COVID-19 vaccine that's 95% effective. The implied meaning here is that the COVID-19...

Links for some of the science are included - this presentation is based on press releases. The peer reviewed data will be available shortly. Some things to note - results show both 64% and 90% effective,the video explains this one The tests looked for positive Covid tests in volunteers...

I have some questions about how the Pfizer mRNA vaccine BNT162b2 (BTN for short) works. BTN codes for the SARS Covid-2 spike protein RNA sequence and is somehow delivered into cells, transcribed and then the proteins are delivered to the outer cell membrane or maybe just protrudes through...

In the New England Journal of Medicine: https://www.nejm.org/doi/full/10.1056/NEJMoa2028436 (also has links to supporting documentation) https://www.nejm.org/doi/pdf/10.1056/NEJMoa2028436?articleTools=true A stage 1 trial with 40 volunteers. "After the second immunization, serum neutralizing...

We are starting to reach the stage when vaccines will be rolled out. I thought it was time to start a thread specifically on the state of play. Just an hour ago the following was published by an Australian newspaper (my precis): 'A vaccine will be available in Australia from the middle of...

Russia's vaccine news has me pondering. How often after a successful phase 2 study do phase 3 studies show that the vaccine causes harm? If I were offered a COVID-19 vaccine that had passed phase 2 trials, I'd accept it. Is that foolhardy of me? Is it possible to use existing data to model...

Hello, is there such a thing as a vaccine “not having any effect” on a person, and for some reason making it a “dud” for that specific person? I guess if the dose isn’t strong enough that could be the case, but is there such a thing of the person not “reacting” to those antibodies for some...

Lancet has a report of a vaccine for the Ebola virus.

Is it true the vaccine and autism link is completely refuted and the original doctor who mentioned the link made it up? I avoided any flu shots because didn't want to get autism.. see the link: Edit: not valid source http://www.cdc.gov/vaccinesafety/concerns/autism.html

This popular press article is interesting: http://medicalxpress.com/news/2016-07-world-alzheimer-vaccine.html Here is the scientific article behind the popular article: http://www.nature.com/articles/srep28912 Does anybody have any knowledge of this topic? It would certainly be a great...

Is this is good as it sounds? http://www.washingtonpost.com/news/morning-mix/wp/2014/05/15/womans-cancer-killed-by-measles-virus-in-unprecedented-trial/

New study out http://www.usatoday.com/story/news/nation/2013/10/22/flu-vaccine-heart-attack/3150819/

Typically I don't post the same in more than one place, I will do it this time: http://www.pharmafile.com/news/181169/calls-end-uk-anti-vaccine-magazine Each time I hear about such things I think of the post mortem photography industry that existed at the end of 19th century...

note: Phase I is just safety testing, not efficacy. Still exciting, though! http://communications.uwo.ca/media/releases/2013/September/no_adverse_effects_in_volunteers_following_phase_i_clinical_trial_of_sumagen_aids_vaccine.html

Does this mean if someone comes into contact with faecally contaminated matter of an immunised polio person, that person would also be vaccinated. Thanks :smile: