Best Method for Calculating Solvent Accessible Surface Area?

AI Thread Summary
The discussion centers on methods for calculating solvent accessible surface area (SASA) in the context of protein folding and protein-ligand docking. Participants mention Midas and MidasPlus as tools previously used for this purpose, noting that MidasPlus has been replaced by Chimera. An overview paper is referenced, which includes a link to MidasPlus and discusses its relevance in computational chemistry. There is a request for information on where to find the code for these tools, indicating a need for accessible resources in this area of study.
hefeweizen
Messages
5
Reaction score
0
Hi,

what do you think is the best method to determine/calculate in a
computationally efficient way the solvent accessible surface area in
phenomena like protein folding or protein-ligand docking ?

Thanks
 
Biology news on Phys.org
This is not my discipline but I recall reading about Midas and MidasPlus a while ago. I think you can still look at the code and see what is going on.

Here is an overview paper, you might take a look, it has a link to MidasPlus.
http://www.netsci.org/Science/Compchem/feature14e.html
 
do you know where the code can be found ?

jim mcnamara said:
This is not my discipline but I recall reading about Midas and MidasPlus a while ago. I think you can still look at the code and see what is going on.

Here is an overview paper, you might take a look, it has a link to MidasPlus.
http://www.netsci.org/Science/Compchem/feature14e.html
 
Deadly cattle screwworm parasite found in US patient. What to know. https://www.usatoday.com/story/news/health/2025/08/25/new-world-screwworm-human-case/85813010007/ Exclusive: U.S. confirms nation's first travel-associated human screwworm case connected to Central American outbreak https://www.reuters.com/business/environment/us-confirms-nations-first-travel-associated-human-screwworm-case-connected-2025-08-25/...
Chagas disease, long considered only a threat abroad, is established in California and the Southern U.S. According to articles in the Los Angeles Times, "Chagas disease, long considered only a threat abroad, is established in California and the Southern U.S.", and "Kissing bugs bring deadly disease to California". LA Times requires a subscription. Related article -...
I am reading Nicholas Wade's book A Troublesome Inheritance. Please let's not make this thread a critique about the merits or demerits of the book. This thread is my attempt to understanding the evidence that Natural Selection in the human genome was recent and regional. On Page 103 of A Troublesome Inheritance, Wade writes the following: "The regional nature of selection was first made evident in a genomewide scan undertaken by Jonathan Pritchard, a population geneticist at the...
Back
Top