The discussion centers on the best software for drawing chemical structures, with a focus on ChemDoodle and ACD Labs ChemSketch. Users highlight ChemDoodle's features, particularly its atom tagging and numbering tools, which auto-increment and enhance usability. One participant mentions using ACD Labs ChemSketch for molecule drawing and adding annotations in Photoshop. There is a consensus that ChemDoodle is superior for chemical drawing, and users are encouraged to reach out to ChemDoodle's support for assistance with any issues, including the online widget version.