To calculate the force exerted on the block by air flowing through the two holes in the lower pipe, Bernoulli's equation and the conservation of mass principles are applicable. The conservation of mass can be expressed as A1v1 + A2v2 + A3v3 + A4v4 = A5v5, where A represents area and v represents velocity. Bernoulli's equation can also be utilized to relate pressures and velocities at different points in the system, assuming atmospheric pressure at the inlets. To determine the force on the block, one should start at the node where the pipes converge, applying the continuity equation to find flow rates, and then use Bernoulli's equation to calculate pressure drops. The discussion highlights the need to assess whether the airflow is sufficient to generate a lifting force on the block.