To calculate Young's Modulus (E) from load and displacement values, it's important to consider the material's stress-strain relationship. For mild steel, a linear region exists, making it straightforward to determine E, while aluminum exhibits a linear relationship only at small strains and lacks a clear yield point. When calculating E for aluminum, it's crucial to note that its behavior can be nonlinear under certain stress levels, affecting the calculation. The formula for E can be derived from force divided by area, multiplied by length, and divided by displacement. Understanding these distinctions is essential for accurate calculations of Young's Modulus for different materials.