Primary, secondary, and tertiary datums must be perpendicular to each other when specified with a perpendicular tolerance on technical drawings. If the print indicates this requirement, the part must conform to it to ensure proper fit and function. However, confirming perpendicularity can be challenging when dealing with a point in space. The discussion highlights the importance of adhering to specified tolerances in engineering and manufacturing processes. Understanding these requirements is crucial for maintaining quality and precision in part production.