To protect a floating power supply not connected to Earth ground, ESD diodes should be connected to the positive and negative terminals of the power supply rather than to ground. Key techniques include ensuring proper packaging to prevent unwanted arcs, maintaining a minimum creepage distance, and clamping exposed pins to a ground plane. An RC circuit is recommended between primary and isolated circuits to prevent high voltage arcing, typically using a 2.7 nF X-class capacitor and a 1 meg-ohm resistor. In medical applications, two capacitors in series are necessary to minimize leakage current risks. Proper handling of battery-operated equipment is crucial, as there may be no discharge path for accumulated charge.