To react an alkyne with a ketone, it is necessary to first treat the alkyne with sodium amide (NaNH2) to generate a nucleophile. This step is crucial for facilitating the reaction with the ketone. The discussion also references a specific experiment involving tetraphenylcyclopentadiene and diphenylacetylene, which was conducted by heating in silicone oil without the use of bases, indicating that alternative methods may exist for alkyne reactions. However, general reactions between alkynes and ketones are not well-documented in the sources consulted.