Building a radio relay station 100 miles apart requires careful consideration of frequency selection, with options including HAM radio bands for licensed users or the ISM band for unlicensed use. High-gain Yagi antennas are recommended for both ends to ensure a strong line-of-sight connection, which is crucial for effective signal transmission. Communication through urban areas presents challenges due to building interference, which can significantly degrade signal quality. For distances over 100 miles, the shortwave band around 10 MHz is suggested, along with specific antenna designs. It's essential to adhere to regulations governing amateur radio to avoid legal issues.