SUBLETHAL REPAIR OF CHROMOSOME DAMAGE FROM IONIZING RADIATION FOR DUMMYS
(corrections welcome - it's been a long time since I studied it)
Joe:
http://en.wikipedia.org/wiki/DNA_repair
Very simplistic explanation: Biochemically, DNA is a two-stranded mega-molecule. Ionizing radiation does chromosome damage by the ionization leading to free radicle formation (O-1, or oxygen free radicles as I recall) which leads to a break in one side of the DNA strand. In brief, at relatively low exposure rates, and even moderate exposure rates of ionizing radiation, it is far more likely that these ionization events result in damage to only one side of the DNA chain. Only if there is enough radiation exposure to cause a "double hit" and a double chain break in the DNA strand, is irreversible damage done to a DNA strand and thus, irreparable chromosomal damage.
Biochemically, there are single strand breaks going on all the time from a number of causes, but the body has a very efficient way of repairing these. Reverse DNA transcriptase attaches to one side of the DNA strand and, in effect by reading one side of the chain, repairs the break in the other side, like a zipper. But if this reparative enzyme encounters a break in both strands simultaneously (both sides of the zipper are broken) it can't make the repair.
But double chain breaks are uncommon except in very high, single exposures to ionizing radiation (alpha, beta, x-ray, gamma), with one exception: alpha particles. This is because of the high mass and double charge of the alpha particle (2P+2N)++ vs beta (1e)- vs x-ray and gamma (photons, no charge). But alphas don't penetrate from external exposure. On the other hand, if you ingest an alpha emitter, you are probably screwed (can I say screwed on this forum?)
At exposure rates sufficient to have a high enough number of ionizing gammas to statistically cause a high number of double chain breaks, then, yes, permanent damage is done. At lower exposures, and probably even moderately high exposures, it is probably business as usual for the DNA machinery of living organisms.
Take a big dose of Vitamins E and C (anti-oxidizing agents, fat and water soluble respectively) if you are worried about low level radiation exposure, and relax. Again, look up the Mega Mouse Project for some interesting reading.
It theoretically might only take one alpha "hit" on a critical part of a cancer forming or cancer preventing chromosome (read up on oncogenes, proto-oncogenes, etc. in your spare time) to start a cancer, perhaps, but the probability of a single ionizing event from any other source of radiation causing a cancer is non-existent, IMO.