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Open Reading Frame?

  1. Sep 11, 2004 #1
    does anyone know what an ORF (open reading frame) is?

    it would help me alot if anyone explains this to me.

    thank you so much!
     
  2. jcsd
  3. Sep 12, 2004 #2

    iansmith

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    http://www.geneed.com/glossary/o/index.html

    The ORF definition has some small differences in bacteria and eukaryotes. Since bacteria have very few genes with introns, an ORF is usually the entire gene coding for a probable protein meaning there is a start codon and a stop codon and close the ORF, regulatory and stoping elements should be found. In bacteria you might also find several ORF close together and sometimes overlapping. This is an operon. In eukaryotes, ORF are usually the exons.
     
  4. Sep 13, 2004 #3
     
  5. Sep 13, 2004 #4

    iansmith

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    an exon has a start and a stop sequence to mark the exon
     
  6. Sep 13, 2004 #5

    uhh! this is something new to me :bugeye:

    thanks alot!
     
  7. Sep 13, 2004 #6

    Monique

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    Those are splice sites.

    An ORF is the reading frame from which DNA is translated into RNA. The initiation codon would be in the first exon and the termination codon in the last. The introns are not spliced out until after the transcription, so I think they do belong to the ORF.

     
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