Production of Tylenol and Advil: Researching Reactions & Factors

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The discussion focuses on the synthesis processes of acetaminophen and ibuprofen, the active ingredients in Tylenol and Advil, respectively. Acetaminophen is produced through the reaction of acetic anhydride and p-aminophenol. In contrast, the synthesis of ibuprofen involves a more complex series of reactions, starting with a Friedel-Crafts reaction using acetyl chloride on an alkyl benzene at the 4-position. This is followed by a two-step process to create a keto group, converting it into an aldehyde, then preparing an oxime, and synthesizing a nitrile from it. The nitrile is subsequently hydrolyzed to yield the final carboxylic acid product. The discussion highlights the challenges in finding detailed information on the production processes for these common over-the-counter medications.
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For a school project, i have to research production of Tylenol and Advil - but i can't find ANYTHING!

- What reactions are involved when producing acetaminophen and ibuprofen?
- What factors affect production of these products?
 
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Tylenol is a commercial drug, which has the main ingredient, acetaminophen aka paracetamol. Ibuprofen is, 2-(p-isobutylphenyl)propionic acid. I found the data on this website. Advil is the second commercial drug, with ibuprofen in it as the main ingredient.

So you are looking a way for their synthesis, right?
 
Actually, i found out that acetaminophen is the synthesis of acetic anhydride and p-aminophenol. But I'm not sure how ibuprofen can be synthesized. Any ideas?
 
I have found this, a Friedel-Crafts reaction with acetyl chloride on alkyl benzene at 4-position, then a mystery-two-step reaction for a keto group to convert it into an aldehyde, preparation of an oxime from it, and synthesis of a nitrile from this one was used. The nitrile is hydrolyzed to give the desired product, the carboxylic acid. This is a cue for you, although this is not a cue anymore :wink:
 

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