Lipid-Water Partition Coefficient: Impact on Hemolysis?

[fatima_a]

is it true that as the lipid water partition coefficient increases, the permeability of lipid increases and the permeability of water lowers. does that mean that a substance w/ a high lipid water partition coeffecient will be able to go through the cell membrane more easily and cause hemolysis faster?

also i know that an increase in molecular weight is related to an increase in the size of the molecule and the larger the molecule the less permeable the membrane is to that molecule, so does that mean that as the molecular weight increases, the less permeable the membrane becomes and therefore it takes more time for hemolysis?

which one plays a bigger role in affecting hemolysis?

thanks

 

[Nino MMP]

in advance Yes, it is true that as the lipid-water partition coefficient increases, the permeability of lipid increases and the permeability of water lowers. This means that a substance with a high lipid-water partition coefficient will be able to go through the cell membrane more easily and cause hemolysis faster. Molecular weight does play a role in affecting hemolysis, as an increase in molecular weight is related to an increase in the size of the molecule, making it less permeable to the membrane. However, the lipid-water partition coefficient is likely to have a bigger role in affecting hemolysis, as a higher partition coefficient corresponds to a greater affinity for the lipid bilayer of the cell membrane, allowing the substance to pass through the membrane more easily.