The sound produced by a musical instrument is primarily a combination of its fundamental frequency and its harmonics, rather than a single sound wave. The fundamental frequency, or ground frequency, has the largest amplitude and determines the perceived pitch, while harmonics contribute to the overall sound quality without altering the pitch. For example, the E string of a guitar produces an E tone at 82.41 Hz as its ground frequency, accompanied by smaller amplitude harmonics. The presence of these harmonics can make the sound appear "noisy" or "unclean," and different instruments exhibit varying levels of harmonic content. The discussion also raises questions about the relationship between harmonics and wave coherence, suggesting a connection between these concepts in physics.