What is the difference between NANC transmitter and co-transmitter?

AI Thread Summary
The discussion centers on the distinction between non-adrenergic non-cholinergic (NANC) transmitters and co-transmitters in neuronal communication. NANC transmitters are defined as those that do not fall into the adrenergic or cholinergic categories, while co-transmitters serve a modulatory role alongside the primary neurotransmitter. Co-transmitters may be released during low-frequency neuronal signaling, whereas the main transmitter is released at higher frequencies. An example provided is glutamate acting as a co-transmitter in dopaminergic neurons, particularly in relation to their functions in the nucleus accumbens. The conversation highlights the complexity of synaptic communication and the specific roles different types of transmitters play.
jayadds
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Hi all,

I was just wondering, what is the difference between non-adrenergic non-cholinergic (NANC) transmitter and co-transmitter in the synaptic communication between neurons? In particular, what are their different functions?

Many thanks,
Jay
 
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jayadds said:
Hi all,

I was just wondering, what is the difference between non-adrenergic non-cholinergic (NANC) transmitter and co-transmitter in the synaptic communication between neurons? In particular, what are their different functions?

Many thanks,
Jay

Co-transmitters are thought to have a modulating function on the neuron-specific transmitter. In some cases the co-transmitter only is released with low-frequency signaling. With higher frequency signaling the main transmitter is also released. I'm not sure why you exclude cholinergic and adrenergic neurons, but in dopaminergic neurons, glutamate has been observed as a co-transmitter. The actions of dopaminergic neurons terminating in the nucleus accumbens (NAc) are described in the linked article (see conclusion).

http://jgp.rupress.org/content/139/1/93.full
 
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