For free fields, given basic creation and destruction operators, you can find the (anti)commutators for arbitrary coordinates, in each field involved. Weinberg's treatment is based on creation and destruction operators( see p173 and on in Vol 1 of his Field Theory treatise, and then go to p201 and following.) Note, also, that the Jacob and Wick helicity formalism preceded Weinberg's treatment.
So, really, Weinberg uses canonical commutation rules, but in a somewhat disguised fashion. My sense is that the key for Weinberg is the Cluster Decomposition Principle.
One of the major players in what might be called practical formal field theory is Gunner Kallen. He was writing in the 1960s about smeared out fields, distributions,commutation rules, propagators, vertex functions and the like. If you want to get a better handle on such matters, find his work, maybe on Google -- my source is the lectures from the 1960 Les Houches summer school in a volume called Dispersion Relations and Elementary Particles, edited by De Witt and Omnes. Yes, it is very old stuff, but still highly relevant and insightful.
And remember, physicists are often sloppy about mathematics -- cf. Goldberger and Watson's Collision Theory. They go into infinite detail about the formal difficulties of the Lippman Schwinger eq., the Heitler Integral Eq, and all of formal scattering theory, which directly connects with field theory. Good stuff to know if you want to understand QM dynamics, whether relativistic or non-relativistic.
Regards,
Reilly