The discussion centers around the susceptibility of zone 1 in the liver to ischemic injury, exploring the anatomical and physiological factors that contribute to this phenomenon. Participants also touch on the implications of eclampsia in relation to zone 1 necrosis, examining both theoretical and clinical aspects.
Participants express differing views on the oxygenation characteristics of portal vein blood and its implications for liver zones. The discussion remains unresolved regarding the exact mechanisms and definitions related to ischemic injury in zone 1.
Some statements rely on specific definitions of oxygenation and nutrient supply, which may not be universally accepted. The discussion also reflects varying interpretations of the physiological roles of the portal and hepatic arterial systems.
sameeralord said:Hi,
Is it because around central vein, there is only deoxygenated blood from the vein where as in the periphery there is hepatic artery. Also why does eclampsia cause zone 1 necrosis. Thanks :)
SW VandeCarr said:Zone 1 is the periportal zone. Although a vein, the portal vein supplies about half the liver's oxygenation in the normal situation, but this is reduced in cirrhosis. The hepatic artery normally supplies the other half. Zone 1 is more prone to toxic and viral injury (hepatitis). Zone 3 is normally the least oxygenated of the hepatic zones and the most prone to ischemic injury.
mazinse said:double check here, the portal vein shouldn't have any oxygen you mean nutrients right from the GI.
to the original question, ecclampsia is a vascular damage, so yeah the logic stands