To control a 110V fan with a low voltage thermostat, an opto-isolating triac is recommended for safe isolation between low and high voltage sides. Beginners are advised to use a simple relay instead, which can be easily sourced from stores like Radio Shack. A line voltage thermostat can replace a wall switch, but caution is necessary to avoid wiring line voltage to low voltage control wires. Designing a safe low voltage controller requires expert knowledge, and using a UL-approved controller is suggested for safety. Proper checks and expert guidance are crucial before any electrical work is attempted.