Friction impacts work calculation in physics by always acting in the opposite direction of displacement, resulting in a negative work value. The calculations for work done by friction can be derived using integral methods or kinetic energy changes, leading to a consistent result of approximately -661J. The importance of significant figures is highlighted, particularly with the example of a 68kg mass, which can affect the final answer. It is emphasized that sharing solutions and methods is beneficial for others learning physics, especially regarding the negative nature of work done by friction. Posting solutions can aid in understanding and provide instructional value for future learners.